Tuberous Sclerosis is a rare disease that causes growths in the skin, brain, kidneys, eyes, heart or lungs - Bright Tots - Information on child development - Autism information.
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Tuberous sclerosis also called tuberous sclerosis complex (TSC) is a rare disease that causes growths in the skin, brain,
kidneys, eyes, heart or lungs. These growths are usually benign (non-cancerous). The first signs of tuberous sclerosis may be
seizures and spots on the skin. Some people who have tuberous sclerosis may have learning problems or seizures that are hard
to control. It commonly affects the central nervous system and results in a mixture of symptoms including seizures,
developmental delay, behavioral problems, skin abnormalities, and kidney disease.

Tuberous sclerosis affects every 1 in 6,000 people in the United States. The disorder occurs in both sexes and in people of all
races and ethnic groups. The disorder affects as many as 25,000 to 40,000 individuals in the United States and about 1 to 2
million individuals worldwide, with an estimated prevalence of one in 6,000 newborns.

Many tuberous sclerosis complex patients show indication of the disorder in the first year of life. However, clinical features can
be faint initially, and many signs and symptoms take years to develop. As a result, tuberous sclerosis can be unrecognized or
misdiagnosed for years.

What causes Tuberous Sclerosis?

Tuberous sclerosis is caused by defects, or mutations, on two genes-TSC1 and TSC2. Only one of the genes needs to be
affected for tuberous sclerosis complex to be present. The TSC1 gene, discovered in 1997, is on chromosome 9 and produces
a protein called hamartin. The TSC2 gene, discovered in 1993, is on chromosome 16 and produces the protein tuberin.
Scientists believe these proteins act in a complex as growth suppressors by inhibiting the activation of a master, evolutionarily
conserved kinase called mTOR. Loss of regulation of mTOR occurs in cells lacking either hamartin or tuberin, and this leads to
abnormal differentiation and development, and to the generation of enlarged cells, as are seen in Tuberous Sclerosis complex
brain lesions.

In familial cases, tuberous sclerosis is an autosomal dominant disorder, which means that the disorder can be transmitted
directly from parent to child. In those cases, only one parent needs to have the faulty gene in order to pass it on to a child. If a
parent has tuberous sclerosis gene, each offspring has a 50 percent chance of developing the disorder. Children who inherit
tuberous sclerosis complex may not have the same symptoms as their parent and they may have either a milder or a more
severe form of the disorder.

Currently, there is no test to identify a person who has the tuberous sclerosis gene if that person has no signs or symptoms of
it. If parents who have one child with tuberous sclerosis want to have another child, they should talk with their family doctor.
The family doctor can refer them to a genetic counselor or medical geneticist who can help them with additional facts.

Although some individuals inherit the disorder from a parent with tuberous sclerosis complex, most cases occur as sporadic
cases due to new, spontaneous mutations in TSC1 or TSC2. In this situation, neither parent has the disorder or the faulty gene
(s). Instead, a faulty gene first occurs in the affected individual.
Rarely, individuals acquire tuberous sclerosis complex through a process called gonadal mosaicism. These patients have parents
with no apparent defects in the two genes that cause the disorder. Yet these parents can have a child with tuberous sclerosis
because a portion of one of the parent's reproductive cells (sperm or eggs) can contain the genetic mutation without the other
cells of the body being involved. In cases of gonadal mosaicism, genetic testing of a blood sample might not reveal the potential
for passing the disease to offspring.

Symptoms of Tuberous Sclerosis

Tuberous sclerosis complex can affect many different systems of the body, causing a variety of signs and symptoms. Signs of
the disorder vary depending on which organism and which limbs are involved. The natural course of tuberous sclerosis
complex varies from individual to individual, with symptoms ranging from very mild to quite severe. In addition to the benign
tumors that frequently occur in tuberous sclerosis, other common symptoms include seizures, mental retardation, behavior
problems, and skin abnormalities. Tumors can grow in nearly any organ, but they most commonly occur in the brain, kidneys,
heart, lungs, and skin. Malignant tumors are rare in tuberous sclerosis complex. Those that do occur primarily affect the

Kidney problems such as cysts and angiomyolipomas occur in an estimated 70 to 80 percent of individuals with tuberous
sclerosis, usually occurring between ages 15 and 30. Cysts are usually small, appear in limited numbers, and cause no serious
problems. Approximately 2 percent of individuals with tuberous sclerosis complex develop large numbers of cysts in a pattern
similar to polycystic kidney disease during childhood. In these cases, kidney function is compromised and kidney failure
occurs. In rare instances, the cysts may bleed, leading to blood loss and anemia.

Three types of brain tumors are associated with tuberous sclerosis complex: cortical tubers, for which the disease is named,
generally form on the surface of the brain, but may also appear in the deep areas of the brain; subependymal nodules, which
form in the walls of the ventricles-the fluid-filled cavities of the brain; and giant-cell tumors (astrocytomas), a type of tumor
that can grow and block the flow of fluids within the brain, causing a buildup of fluid and pressure and leading to headaches
and blurred vision.

Tumors called cardiac rhabdomyomas are often found in the hearts of infants and young children with tuberous sclerosis. If the
tumors are large or there are multiple tumors, they can block circulation and cause death. However, if they do not cause
problems at birth-when in most cases they are at their largest size-they usually become smaller with time and do not affect the
individual in later life.

Benign tumors called phakomas are sometimes found in the eyes of individuals with tuberous sclerosis complex, appearing as
white patches on the retina. Generally they do not cause vision loss or other vision problems, but they can be used to help
diagnose the disease.  Additional tumors and cysts may be found in other areas of the body, including the liver, lung, and
pancreas. Bone cysts, rectal polyps, gum fibromas, and dental pits may also occur.

A wide variety of skin abnormalities may occur in individuals with tuberous sclerosis. Most cause no problems but are helpful
in diagnosis. Some cases may cause disfigurement, necessitating treatment. The most common skin abnormalities include:

•        Hypomelanic macules ("ash leaf spots"), which are white or lighter patches of skin that appear anywhere on the body and
are caused by a lack of skin pigment or melanin-the substance that gives skin its color.
•        Reddish spots or bumps called facial angiofibromas (also called adenoma sebaceum), which appear on the face
(sometimes resembling acne) and consist of blood vessels and fibrous tissue.
•        Raised, discolored areas on the forehead called forehead plaques, which are common and unique to tuberous sclerosis
complex and may help doctors diagnose the disorder.
•        Areas of thick leathery, pebbly skin called shagreen patches, usually found on the lower back or nape of the neck.
•        Small fleshy tumors called ungual or subungual fibromas that grow around and under the toenails or fingernails and may
need to be surgically removed if they enlarge or cause bleeding. These usually appear later in life, ages 20 - 50.
•        Other skin features that are not unique to individuals with tuberous sclerosis complex, including molluscum fibrosum or
skin tags, which typically occur across the back of the neck and shoulders, café au lait spots or flat brown marks, and poliosis,
a tuft or patch of white hair that may appear on the scalp or eyelids.

Mental Ability of Children with Tuberous Sclerosis Complex

Approximately one-half to two-thirds of individuals with tuberous sclerosis complex have mental disabilities ranging from mild
learning disabilities to severe mental retardation. Behavior problems, including aggression, sudden rage, attention deficit
hyperactivity disorder, acting out, obsessive-compulsive disorder, and repetitive, destructive, or self-harming behavior, often
occur in children with tuberous sclerosis, and can be difficult to manage. Some individuals with tuberous sclerosis complex
may also have a developmental disorder called autism.

Tuberous sclerosis can cause seizures and varying degrees of mental disability. Seizures of all types may occur, including
infantile spasms; tonic-clonic seizures (also known as grand mal seizures); or tonic, akinetic, atypical absence, myoclonic,
complex partial, or generalized seizures.

Your doctor may suspect tuberous sclerosis if your baby has a condition called cardiac rhabdomyomas (benign heart tumors) at
birth or starts to have seizures, especially a kind of seizure called infantile spasms.

Diagnosis of Tuberous Sclerosis Complex

In most cases the first clue to recognizing tuberous sclerosis complex is the presence of seizures or delayed development. In
other cases, the first sign may be white patches on the skin (hypomelanotic macules). Diagnosis of the disorder is based on a
careful clinical exam in combination with computed tomography (CT) or magnetic resonance imaging (MRI) of the brain,
which may show tubers in the brain, and an ultrasound of the heart, liver, and kidneys, which may show tumors in those
organs. Doctors should carefully examine the skin for the wide variety of skin features, the fingernails and toenails for ungual
fibromas, the teeth and gums for dental pits and/or gum fibromas, and the eyes for dilated pupils. A Wood's lamp or ultraviolet
light may be used to locate the hypomelantic macules which are sometimes hard to see on infants and individuals with pale or
fair skin. Because of the wide variety of signs of tuberous sclerosis complex it is best if a doctor experienced in the diagnosis of
tuberous sclerosis complex evaluates a potential patient.

In infants tuberous sclerosis complex may be suspected if the child has cardiac rhabdomyomas or seizures (infantile spasms) at
birth. With a careful examination of the skin and brain, it may be possible to diagnose tuberous sclerosis complex in a very
young infant. However, many children are not diagnosed until later in life when their seizures begin and other symptoms such
as facial angiofibromas appear.

Tuberous Sclerosis Treatment

Unfortunately, there is no cure for tuberous sclerosis, although treatment is available for a number of the symptoms.  For
example, medicine can help control seizures and surgery can remove any growths. If your child has developmental problems,
occupational therapy can help. Most people who have tuberous sclerosis have a normal life span.

Treatment for tuberous sclerosis antiepileptic drugs may be used to control seizures, and medications may be prescribed for
behavior problems. Intervention programs including special schooling and occupational therapy may benefit individuals with
special needs and developmental issues. Surgery including dermabrasion and laser is useful treatment for skin lesions. Some
with the tuberous sclerosis is a lifelong condition; individuals need to be regularly monitored by a doctor to make sure they are
receiving the best possible treatments. Due to the many varied symptoms of tuberous sclerosis complex, care by a clinician
experienced with the disorder is recommended.

Tuberous Sclerosis Complex Prognosis

The prognosis for individuals with tuberous sclerosis complex depends on the severity of symptoms, which range from mild
skin abnormalities to varying degrees of learning disabilities and epilepsy to severe mental retardation, uncontrollable seizures,
and kidney failure. Those individuals with mild symptoms generally do well and live long productive lives, while individuals with
the more severe form may have serious disabilities.

In rare cases, seizures, infections, or tumors in vital organs may cause complications in some organs such as the kidneys and
brain that can lead to severe difficulties and even death. However, with appropriate medical care, most individuals with the
disorder can look forward to normal life expectancy.